Zoltero 4 Description

Each vial contains Zoledronic Acid Monohydrate 4.264 mg Equivalent to Zoledronic acid 4 mg.
Zoledronic acid, a bisphosphonic acid which is an inhibitor of osteoclastic bone resorption. Zoledronic acid is designated chemically as (1-Hydroxy-2-imidazol-1-yl-phosphonoethyl) phosphonic acid monohydrate.
Zoledronic acid is a white crystalline powder. Its molecular formula is C₅H₁₀N₂O₇P₂ H₂O and its molar mass is 290.1g/Mol. Zoledronic acid is highly soluble in 0.1N sodium hydroxide solution, sparingly soluble in water and 0.1N hydrochloric acid, and practically insoluble in organic solvents. The pH of a 0.7% solution of zoledronic acid in water is approximately 2.0.
Zoledronic acid is available in 100-mL bottles as a sterile liquid ready-to-use solution for intravenous infusion and in 5-mL vials as a sterile liquid concentrate solution for intravenous infusion.
Excipients/Inactive Ingredients: Mannitol (Pearlitol PF), Ph.Eur, 220 mg, water for injection and trisodium citrate dehydrate, Ph. Eur to adjust pH.